Set in 1970s Rome, the fiction tracks the plight of a nuclear family, consisting of an unhappy married couple Clara (a deeply dissatisfied expatriate Spaniard) and Felice (an abusive businessman cheating on Clara with his secretary) and their children Adriana, Gino, and Diana. Their eldest child, 12-year-old Adriana, experiences gender dysphoria; he rejects girlhood and instead goes by the name of Andrea (a primarily masculine name in Italian). Andrea develops a crush for Sara, a Roma girl who knows him as a boy. Upon a shared sense of being outsiders, Andrea and Clara grow closer.